Novel aqueous biphasic system based on ethyl lactate for sustainable separations : Phase splitting mechanism

Kamalanathan, Ishara and Petrovski, Zeljko and Branco, Luis C. and Najdanovic-Visak, Vesna (2018) Novel aqueous biphasic system based on ethyl lactate for sustainable separations : Phase splitting mechanism. Journal of Molecular Liquids, 262. pp. 37-45. ISSN 0167-7322

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Ethyl lactate is a hydrophilic green solvent which is bio-renewable and biodegradable with low toxicity towards humans and animals. For the first time, we report that aqueous solutions of ethyl lactate separate into two aqueous phases upon addition of salts. The performance of trisodium citrate, disodium tartrate and disodium succinate as salting-out media for the separation of natural organic compounds, such as caffeine and catechin, from their aqueous solutions was examined. In this respect, cloud points for the ternary solutions composed of ethyl lactate, water and salt were determined at ambient pressure (0.1 MPa) at 298.2 K. Partition coefficients of caffeine and catechin between two phases were determined by chemical analysis of phases in equilibrium for different initial compositions at 298.2 K. The obtained results clearly demonstrate the ability of the ternary mixture to phase separate, providing good salting-out media for the efficient and sustainable separation from aqueous solution. 1H NMR spectroscopy was employed to elucidate the mechanisms of phase splitting in the ternary (ethyl lactate + water + salt) systems at molecular level. The discovery of aqueous biphasic system (ABS) containing ethyl lactate as hydrophilic solvent opens a new and green platform for extraction of various compounds from aqueous solutions.

Item Type:
Journal Article
Journal or Publication Title:
Journal of Molecular Liquids
Additional Information:
This is the author’s version of a work that was accepted for publication in Journal of Molecular Liquids. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Molecular Liquids, 262, 2018 DOI: 10.1016/j.molliq.2019.03.119
Uncontrolled Keywords:
?? aqueous two-phase systemgreen extractionnatural organic compoundsmaterials chemistryspectroscopyatomic and molecular physics, and opticsphysical and theoretical chemistryelectronic, optical and magnetic materialscondensed matter physics ??
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Deposited On:
06 Apr 2018 15:46
Last Modified:
31 Dec 2023 00:56