Mitotic inhibition of clathrin-mediated endocytosis

Fielding, Andrew B. (2013) Mitotic inhibition of clathrin-mediated endocytosis. Cellular and Molecular Life Sciences : CMLS, 70 (18). pp. 3423-3433. ISSN 1420-682X

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Abstract

Endocytosis and mitosis are fundamental processes in a cell's life. Nearly 50 years of research suggest that these processes are linked and that endocytosis is shut down as cells undergo the early stages of mitosis. Precisely how this occurs at the molecular level is an open question. In this review, we summarize the early work characterizing the inhibition of clathrin-mediated endocytosis and discuss recent challenges to this established concept. We also set out four proposed mechanisms for the inhibition: mitotic phosphorylation of endocytic proteins, altered membrane tension, moonlighting of endocytic proteins, and a mitotic spindle-dependent mechanism. Finally, we speculate on the functional consequences of endocytic shutdown during mitosis and where an understanding of the mechanism of inhibition will lead us in the future.

Item Type:
Journal Article
Journal or Publication Title:
Cellular and Molecular Life Sciences : CMLS
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/3000/3004
Subjects:
ID Code:
124353
Deposited By:
Deposited On:
03 Apr 2018 14:08
Refereed?:
Yes
Published?:
Published
Last Modified:
22 Jul 2020 04:36