The X proteins of bornaviruses interfere with type I interferon signalling

Wensman, Jonas Johansson and Munir, Muhammad and Thaduri, Srinivas and Hörnaeus, Katarina and Rizwan, Muhammad and Blomström, Anne-Lie and Briese, Thomas and Lipkin, W Ian and Berg, Mikael (2013) The X proteins of bornaviruses interfere with type I interferon signalling. Journal of General Virology, 94 (2). pp. 263-269. ISSN 0022-1317

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Borna disease virus (BDV) is a neurotropic, negative-stranded RNA virus causing persistent infection and progressive neurological disorders in a wide range of warm-blooded animals. The role of the small non-structural X protein in viral pathogenesis is not completely understood. Here we investigated whether the X protein of BDV and avian bornavirus (ABV) interferes with the type I interferon (IFN) system, similar to other non-structural proteins of negative-stranded RNA viruses. In luciferase reporter assays, we found that the X protein of various bornaviruses interfered with the type I IFN system at all checkpoints investigated, in contrast to previously reported findings, resulting in reduced type I IFN secretion.

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Journal Article
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Journal of General Virology
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21 Mar 2018 11:06
Last Modified:
22 Nov 2022 05:39