Coupling of Rigor Mortis and Intestinal Necrosis during C. elegans Organismal Death

Galimov, Evgeniy R and Pryor, Rosina E and Poole, Sarah E and Benedetto, Alexandre and Pincus, Zachary and Gems, David (2018) Coupling of Rigor Mortis and Intestinal Necrosis during C. elegans Organismal Death. Cell Reports, 22 (10). pp. 2730-2741. ISSN 2211-1247

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Abstract

Organismal death is a process of systemic collapse whose mechanisms are less well understood than those of cell death. We previously reported that death in C. elegans is accompanied by a calcium-propagated wave of intestinal necrosis, marked by a wave of blue autofluorescence (death fluorescence). Here, we describe another feature of organismal death, a wave of body wall muscle contraction, or death contraction (DC). This phenomenon is accompanied by a wave of intramuscular Ca2+release and, subsequently, of intestinal necrosis. Correlation of directions of the DC and intestinal necrosis waves implies coupling of these death processes. Long-lived insulin/IGF-1-signaling mutants show reduced DC and delayed intestinal necrosis, suggesting possible resistance to organismal death. DC resembles mammalian rigor mortis, a postmortem necrosis-related process in which Ca2+influx promotes muscle hyper-contraction. In contrast to mammals, DC is an early rather than a late event in C. elegans organismal death. VIDEO ABSTRACT.

Item Type:
Journal Article
Journal or Publication Title:
Cell Reports
Additional Information:
Copyright © 2018 The Author(s). Published by Elsevier Inc. All rights reserved.
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/1300
Subjects:
ID Code:
124032
Deposited By:
Deposited On:
15 Mar 2018 10:54
Refereed?:
Yes
Published?:
Published
Last Modified:
16 Sep 2020 04:22