Efficient synthesis of supported proline catalysts for asymmetric aldol reactions

Elmekawy, A. A. and Sweeney, J. B. and Brown, D. R. (2015) Efficient synthesis of supported proline catalysts for asymmetric aldol reactions. Catalysis Science and Technology, 5 (2). pp. 690-696. ISSN 2044-4753

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Abstract

Proline has been grafted onto silica supports in a single step by reacting trans-4-hydroxy-L-proline with chloropropyl tethers, without the use of protecting groups for the proline amine and carboxylic acid functional groups. The resulting catalysts have been characterised to show that grafting is through reaction with the 4-hydroxy group. The catalysts have been tested in an asymmetric aldol reaction, and shown to be both more active and more enantioselective than equivalent catalysts prepared using a protection/deprotection route for the proline grafting step.

Item Type:
Journal Article
Journal or Publication Title:
Catalysis Science and Technology
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/1500/1503
Subjects:
ID Code:
123723
Deposited By:
Deposited On:
26 Feb 2018 12:16
Refereed?:
Yes
Published?:
Published
Last Modified:
24 Mar 2020 06:22