Human subarachnoid space width oscillations in the resting state

Gruszecki, Marcin and Lancaster, Gemma and Stefanovska, Aneta and Neary, J. Patrick and Dech, Ryan T. and Guminski, Wojciech and Frydrychowski, Andrzej F. and Kot, Jacek and Winklewski, Pawel J. (2018) Human subarachnoid space width oscillations in the resting state. Scientific Reports, 8. ISSN 2045-2322

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Abstract

Abnormal cerebrospinal fluid (CSF) pulsatility has been implicated in patients suffering from various diseases, including multiple sclerosis and hypertension. CSF pulsatility results in subarachnoid space (SAS) width changes, which can be measured with near-infrared transillumination backscattering sounding (NIR-T/BSS). The aim of this study was to combine NIR-T/BSS and wavelet analysis methods to characterise the dynamics of the SAS width within a wide range of frequencies from 0.005 to 2 Hz, with low frequencies studied in detail for the first time. From recordings in the resting state, we also demonstrate the relationships between SAS width in both hemispheres of the brain, and investigate how the SAS width dynamics is related to the blood pressure (BP). These investigations also revealed influences of age and SAS correlation on the dynamics of SAS width and its similarity with the BP. Combination of NIR-T/BSS and time-frequency analysis may open up new frontiers in the understanding and diagnosis of various neurodegenerative and ageing related diseases to improve diagnostic procedures and patient prognosis.

Item Type:
Journal Article
Journal or Publication Title:
Scientific Reports
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/1000
Subjects:
ID Code:
123565
Deposited By:
Deposited On:
22 Feb 2018 13:14
Refereed?:
Yes
Published?:
Published
Last Modified:
01 Jul 2020 04:20