Lysine metabolism in higher plants.

Azevedo, R. A. and Lea, P. J. (2001) Lysine metabolism in higher plants. Amino Acids, 20 (3). pp. 261-279. ISSN 0939-4451

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The essential amino acid lysine is synthesised in higher plants via a pathway starting with aspartate, that also leads to the formation of threonine, methionine and isoleucine. Enzyme kinetic studies and the analysis of mutants and transgenic plants that overaccumulate lysine, have indicated that the major site of the regulation of lysine synthesis is at the enzyme dihydrodipicolinate synthase. Despite this tight regulation, there is strong evidence that lysine is also subject to catabolism in plants, specifically in the seed. The two enzymes involved in lysine breakdown, lysine 2-oxoglutarate reductase (also known as lysine α-ketoglutarate reductase) and saccharopine dehydrogenase exist as a single bifunctional protein, with the former activity being regulated by lysine availability, calcium and phosphorylation/dephosphorylation.

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Journal Article
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Amino Acids
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24 Jul 2008 08:39
Last Modified:
14 Sep 2023 23:34