https://eprints.lancs.ac.uk/id/eprint/19595 2020-01-01T06:16:13Z info:eu-repo/semantics/descriptiveMetadata https://eprints.lancs.ac.uk/id/eprint/19595/ Persistent grossly elevated erythrocyte sedimentation rate in elderly people: one year follow-up of morbidity and mortality. Stevens, D. T. Tallis, R. Hollis, S. The significance of a very elevated erythrocyte sedimentation rate (ESR) in elderly patients is debated. In a retrospective study, we searched the records of a laboratory providing the sole service to a health district for ESR measurement and identified all non-surgical and non-psychiatric patients over the age of 65 who had had an ESR above 50 mm/h. Diagnoses and mortality in a 1-year follow-up were determined from case notes. Four hundred and nine subjects (median age 75; range 65-99) were identified and data on 401 of these (155 male, 246 female; median ESR 80 mm/h, range 50-148) were adequate for 1 year follow-up. Forty-eight percent had a persistently raised ESR (two values > 50 mm/h separated by at least 14 days; group 1); 39% had a single ESR measurement only (group 2), and 13% had a transiently raised ESR (group 3). The commonest diagnosis in group 1 patients was rheumatological disease (51.8%), followed by infection (31.9%) and non-haematological malignancy (11%). Infection was the commonest diagnosis in groups 2 (47.4%) and 3 (43.7%), followed by non-haematological malignancy (19.9%) in group 2 and rheumatological disease (20.4%) in group 3. In only 1 in 20 cases was no diagnosis apparent at 1 year. The standardised mortality ratio (SMR) of the combined groups 1 and 2 (482; CI: 421-544) was strikingly raised, and even more so if patients with rheumatoid arthritis were excluded (542; CI 458-625). Where there were sufficient numbers of deaths to make SMR estimations valid, a gradient of mortality against the level of the ESR could be observed. 1995 Journal Article PeerReviewed Stevens, D. T. and Tallis, R. and Hollis, S. (1995) Persistent grossly elevated erythrocyte sedimentation rate in elderly people: one year follow-up of morbidity and mortality. Gerontology, 41 (4). pp. 220-226. ISSN 1423-0003 info:eu-repo/semantics/humanStartPage