Perfect Simulation From Nonneutral Population Genetic Models: Variable Population Size and Population Subdivision.

Fearnhead, Paul (2006) Perfect Simulation From Nonneutral Population Genetic Models: Variable Population Size and Population Subdivision. Genetics, 174. pp. 1397-1406. ISSN 1943-2631

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Abstract

We show how the idea of monotone coupling from the past can produce simple algorithms for simulating samples at a nonneutral locus under a range of demographic models. We specifically consider a biallelic locus and either a general variable population size mode or a general migration model for population subdivision. We investigate the effect of demography on the efficacy of selection and the effect of selection on genetic divergence between populations.