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Intervention effects in observational survival studies with an application in total hip replacements.

Friede, Tim; and Henderson, Robin (2003) Intervention effects in observational survival studies with an application in total hip replacements. Statistics in Medicine, 22 (24).

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Abstract

Time to revision is a common and clinically relevant endpoint for studies of patients with total hip replacement. Because failures occur rarely within the first years after replacement, new surgical techniques and materials are often implemented without evidence of their effectiveness from randomized trials. Observational data may be available but this relies on the use of historical controls which has been heavily criticized. Instead the use of change-point methods has been suggested to detect changes caused by successfully implemented interventions. In the setting of a proportional hazards model we develop a semi-parametric changepoint method to detect changes in baseline hazard. The procedure is motivated by and applied to a clinical study in patients with total hip replacements, where the effect of a new cement type is of interest. Power properties of the proposed method are investigated.

Item Type: Article
Journal or Publication Title: Statistics in Medicine
Uncontrolled Keywords: changepoint • proportional hazards model • observational study • total hip replacement
Subjects: Q Science > QA Mathematics
Departments: Faculty of Science and Technology > Mathematics and Statistics
ID Code: 9819
Deposited By: Mrs Yaling Zhang
Deposited On: 20 Jun 2008 11:33
Refereed?: Yes
Published?: Published
Last Modified: 26 Jul 2012 18:41
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/9819

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