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Niche metabolism in parasitic protozoa.

Ginger, Michael L. (2006) Niche metabolism in parasitic protozoa. Philosophical Transactions of the Royal Society of London Series B - Biological Sciences, 361 (1465). pp. 101-118. ISSN 0962-8436

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Abstract

Complete or partial genome sequences have recently become available for several medically and evolutionarily important parasitic protozoa. Through the application of bioinformatics complete metabolic repertoires for these parasites can be predicted. For experimentally intractable parasites insight provided by metabolic maps generated in silico has been startling. At its more extreme end, such bioinformatics reckoning facilitated the discovery in some parasites of mitochondria remodelled beyond previous recognition, and the identification of a non-photosynthetic chloroplast relic in malarial parasites. However, for experimentally tractable parasites, mapping of the general metabolic terrain is only a first step in understanding how the parasite modulates its streamlined, yet still often puzzlingly complex, metabolism in order to complete life cycles within host, vector, or environment. This review provides a comparative overview and discussion of metabolic strategies used by several different parasitic protozoa in order to subvert and survive host defences, and illustrates how genomic data contribute to the elucidation of parasite metabolism.

Item Type: Article
Journal or Publication Title: Philosophical Transactions of the Royal Society of London Series B - Biological Sciences
Uncontrolled Keywords: parasitic protozoa ; host–pathogen interaction ; comparative genomics ; Trypanosoma ; Leishmania ; Apicomplexa
Subjects: Q Science > QH Natural history > QH301 Biology
Departments: Faculty of Health and Medicine > Biomedical & Life Sciences
ID Code: 9641
Deposited By: Dr Michael Ginger
Deposited On: 17 Jun 2008 15:04
Refereed?: Yes
Published?: Published
Last Modified: 26 Jul 2012 18:40
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/9641

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