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RNA Interference Mutant Induction In Vivo Demonstrates the Essential Nature of Trypanosome Flagellar Function during Mammalian Infection.

Griffiths, Samantha and Portman, Neil and Taylor, Philip R. and Gordon, Siamon and Ginger, Michael L. and Gull, Keith (2007) RNA Interference Mutant Induction In Vivo Demonstrates the Essential Nature of Trypanosome Flagellar Function during Mammalian Infection. Eukaryotic Cell, 6 (7). pp. 1248-1250. ISSN 1535-9778

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Abstract

We demonstrate that trypanosomes compromised in flagellar function are rapidly cleared from infected mice. Analysis of the PFR2 bloodstream RNA interference mutant revealed that defective cell motility occurred prior to cytokinesis failure. This validation provides a paradigm for the flagellum as a target for future assays and interventions against this human pathogen.

Item Type: Article
Journal or Publication Title: Eukaryotic Cell
Subjects: Q Science > QH Natural history > QH301 Biology
Departments: Faculty of Health and Medicine > Biomedical & Life Sciences
ID Code: 9621
Deposited By: Dr Michael Ginger
Deposited On: 17 Jun 2008 15:08
Refereed?: Yes
Published?: Published
Last Modified: 26 Jul 2012 18:40
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/9621

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