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Role of Neisseria meningitidis luxS in Cell-to-Cell Signaling and Bacteremic Infection.

Winzer, Klaus and Sun, Yao-hui and Green, Andrew and Delory, Marie and Blackley, David and Hardie, Kim R. and Baldwin, Thomas J. and Tang, Christoph M. (2002) Role of Neisseria meningitidis luxS in Cell-to-Cell Signaling and Bacteremic Infection. Infection and Immunity, 70 (4). pp. 2245-2248. ISSN 0019-9567

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Abstract

Numerous pathogenic bacteria contain luxS, which is required for autoinducer-2 production. Here, we demonstrate that Neisseria meningitidis contains a functional copy of luxS that is necessary for full meningococcal virulence; strains with a luxS deletion are defective for bacteremia, a prerequisite of meningococcal pathogenesis.

Item Type: Article
Journal or Publication Title: Infection and Immunity
Subjects: Q Science > QH Natural history > QH301 Biology
Departments: Faculty of Health and Medicine > Biomedical & Life Sciences
ID Code: 9551
Deposited By: Dr Klaus Winzer
Deposited On: 13 Jun 2008 14:15
Refereed?: Yes
Published?: Published
Last Modified: 26 Jul 2012 18:38
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/9551

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