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Angiotensin-converting enzyme as a target for the development of novel insect growth regulators.

Isaac, R. Elwyn and Lamango, Nazarius S. and Ekbote, Uma and Taylor, C. A. and Hurst, Debra and Weaver, Robert J. and Carhan, Ahmet and Burnham, Susan and Shirras, Alan D. (2007) Angiotensin-converting enzyme as a target for the development of novel insect growth regulators. Peptides, 28 (1). pp. 153-162. ISSN 0196-9781

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Abstract

Insect angiotensin converting enzyme (ACE) is a zinc metallopeptidase capable of inactivating a variety of small to medium size peptide hormones by cleavage of C-terminal dipeptides and dipeptideamides. High levels of ACE activity are found in the hemolymph and in reproductive tissues of insects, where the enzyme is considered to have an important role in the metabolism of bioactive peptides. Therefore, inhibiting ACE activity is expected to interfere with the peptidergic endocrine system and to have detrimental effects on growth, development and reproduction. We will review the studies showing that ACE inhibitors do indeed disrupt growth and reproduction in various insect species. We will also present some new genetic and pharmacological data that strengthens our conclusion that ACE should be considered as a potential target for the development of new insect growth regulators.

Item Type: Article
Journal or Publication Title: Peptides
Uncontrolled Keywords: Insect control ; Angiotensin-converting enzyme ; Reproduction ; Peptidase ; ANCE ; ACE inhibitors
Subjects: Q Science > QH Natural history > QH301 Biology
Departments: Faculty of Science and Technology > Lancaster Environment Centre
Faculty of Health and Medicine > Biomedical & Life Sciences
ID Code: 9401
Deposited By: Dr Alan Shirras
Deposited On: 09 Jun 2008 09:21
Refereed?: Yes
Published?: Published
Last Modified: 28 Aug 2013 14:59
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/9401

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