Bentley, J. and Walker, I. and McIntosh, E. and Whetton, Anthony D. and Owen-Lynch, P. Jane and Baldwin, S. A. (2001) Glucose transport regulation by p210 Bcr-Abl in a chronic myeloid leukaemia model. British Journal of Haematology, 112 (1). pp. 212-215. ISSN 0007-1048Full text not available from this repository.
The regulation of nutrient transport by both cytokines and oncogenes has been linked to haemopoietic cell survival. In this study, we found that activation of Bcr–Abl protein tyrosine kinase was associated with the stimulation of glucose transport in the multipotent haemopoietic cell line FDCP-mix, a cell model for chronic-phase chronic myeloid leukaemia (CML). Bcr–Abl upregulation of glucose transport was mediated by phosphatidylinositol-3-kinase. The observation that Bcr–Abl can regulate glucose transport in a CML cell model raises the possibility that glucose transport regulation may have a role to play in the aberrant survival of stem cells in the chronic phase of CML.
|Journal or Publication Title:||British Journal of Haematology|
|Subjects:||Q Science > QH Natural history > QH301 Biology|
|Departments:||Faculty of Health and Medicine > Biomedical & Life Sciences|
|Deposited By:||Dr P Jane Owen-Lynch|
|Deposited On:||03 Jun 2008 09:55|
|Last Modified:||07 Jan 2015 16:15|
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