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Glucose transport regulation by p210 Bcr-Abl in a chronic myeloid leukaemia model.

Bentley, J. and Walker, I. and McIntosh, E. and Whetton, Anthony D. and Owen-Lynch, P. Jane and Baldwin, S. A. (2001) Glucose transport regulation by p210 Bcr-Abl in a chronic myeloid leukaemia model. British Journal of Haematology, 112 (1). pp. 212-215. ISSN 0007-1048

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Abstract

The regulation of nutrient transport by both cytokines and oncogenes has been linked to haemopoietic cell survival. In this study, we found that activation of Bcr–Abl protein tyrosine kinase was associated with the stimulation of glucose transport in the multipotent haemopoietic cell line FDCP-mix, a cell model for chronic-phase chronic myeloid leukaemia (CML). Bcr–Abl upregulation of glucose transport was mediated by phosphatidylinositol-3-kinase. The observation that Bcr–Abl can regulate glucose transport in a CML cell model raises the possibility that glucose transport regulation may have a role to play in the aberrant survival of stem cells in the chronic phase of CML.

Item Type: Article
Journal or Publication Title: British Journal of Haematology
Subjects: Q Science > QH Natural history > QH301 Biology
Departments: Faculty of Health and Medicine > Biomedical & Life Sciences
ID Code: 9267
Deposited By: Dr P Jane Owen-Lynch
Deposited On: 03 Jun 2008 09:55
Refereed?: Yes
Published?: Published
Last Modified: 26 Jul 2012 18:34
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/9267

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