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The influence of dietary and environmental factors on prostate cancer risk.

Kooiman, G. and Martin, Francis L. and Williams, J. A. and Grover, Philip L. and Phillips, David H. and Muir, Gordon H. (2000) The influence of dietary and environmental factors on prostate cancer risk. Prostate Cancer and Prostatic Diseases, 3 (4). pp. 256-258. ISSN 1365-7852

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Abstract

Prostate cancer is the most common malignancy found in males and one of the most common causes of cancer death. The epidemiology implicates environmental and nutritional factors in the initiation and progression of the disease. Identification of these factors would allow chemoprevention strategies to be tested. Potent mutagenic and carcinogenic heterocyclic amines and polycyclic aromatic hydrocarbons are produced in cooked meat, and following metabolic activation some of them are strongly associated with prostate carcinogenesis in rodents. Primary cell cultures of human prostate epithelial cells were obtained from patients undergoing transurethral resection of the prostate. Metabolic activation of the cooked food carcinogens 2-amino-1-methyl-6-phenylimidazo- [4,5-b]pyridine (PhIP) and benzo[a]pyrene (B[a]P) was examined and resultant DNA damage (single strand breaks) measured using the Comet assay. Increased concentrations of carcinogen were associated with increased DNA damage and comet tail length compared to controls.

Item Type: Article
Journal or Publication Title: Prostate Cancer and Prostatic Diseases
Subjects: Q Science > QH Natural history > QH301 Biology
Departments: Faculty of Science and Technology > Lancaster Environment Centre
ID Code: 9215
Deposited By: Dr Francis L Martin
Deposited On: 30 May 2008 13:40
Refereed?: Yes
Published?: Published
Last Modified: 26 Jul 2012 18:33
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/9215

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