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An observational study of cancers among female partners of UK-resident prostate cancer patients.

Ragavan, Narasimhan and Grover, Philip and Balasubramanian, Sabapathy P. and Hindley, Andrew C. and Matanhelia, Shyam S. and Martin, Francis L. (2006) An observational study of cancers among female partners of UK-resident prostate cancer patients. Cancer Letters, 242 (1). pp. 88-94. ISSN 0304-3835

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Abstract

Epidemiological studies suggest that environment plays an important role in the aetiology of cancer. Thus, if a cancer (e.g. prostate cancer (CaP)) arises in males, one could hypothesize that risk in co-habiting partners might be elevated. We conducted an observational-questionnaire study in NorthWest England evaluating the medical histories of CaP males and their female partners. Details regarding previous partners (>10 y) were also sought. Self-filled questionnaires were obtained from 548 males, 81 of whom provided information on previous female partners (PFPs) and 448 current female partners (CFPs). Observed rates over a 30-y period (1971–2001) of common cancers (breast, colorectal or lung) in female partners and colorectal cancer in males were compared to the cumulative expected probability (estimated using crude incidence rates for England provided by the Office of National Statistics, UK) using a Chi-Square Goodness-of-Fit test. Colorectal cancers in males were similar to national estimates. Rates for breast, colorectal or lung cancer among CFPs and the total female cohort (CFPs plus PFPs) were also similar to estimates. However, observed rates for breast or lung cancers among PFPs were significantly (P≤0.001) elevated. Our results suggest no evidence of elevated risk among female partners of CaP males.

Item Type: Article
Journal or Publication Title: Cancer Letters
Uncontrolled Keywords: Prostate cancer ; Breast cancer ; NorthWest England ; Observed rates ; Cumulative expected probability ; Shared environmental exposures
Subjects: Q Science > QH Natural history > QH301 Biology
Departments: Faculty of Health and Medicine > Medicine
Faculty of Science and Technology > Lancaster Environment Centre
ID Code: 9176
Deposited By: Dr Francis L Martin
Deposited On: 30 May 2008 13:58
Refereed?: Yes
Published?: Published
Last Modified: 26 Jul 2012 18:33
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/9176

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