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Apoptosis-like death as a feature of malaria infection in mosquitoes.

Hurd, H. and Grant, Karen M. and Arambage, S. C. (2006) Apoptosis-like death as a feature of malaria infection in mosquitoes. Parasitology, 132 (Supple). S33-S47. ISSN 0031-1820

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    Abstract

    Malaria parasites of the genus Plasmodium make a hazardous journey through their mosquito vectors. The majority die in the process, many as a result of the action of mosquito defence mechanisms. The mosquito too is not unscathed by the encounter with these parasites. Tissue damage occurs as a result of mid-gut invasion and reproductive fitness is lost when many developing ovarian follicles are resorbed. Here we discuss some of the mechanisms that are involved in killing the parasite and in the self-defence mechanisms employed by the mosquito to repair the mid-gut epithelium and to manipulate resources altering the trade-off position that balances reproduction and survival. In all cases, cells die by apoptotic-like mechanisms. In the midgut cells, apoptosis-induction pathways are being elucidated, the molecules involved in apoptosis are being recognised and Drosophila homologues sought. The death of ookinetes in the mosquito mid-gut lumen is associated with caspase-like activity and, although homologues of mammalian caspases are not present in the malaria genome, other cysteine proteases that are potential candidates have been discussed. In the ovary, apoptosis of patches of follicular epithelial cells is followed by resorption of the developing follicle and a subsequent loss of egg production in that follicle.

    Item Type: Article
    Journal or Publication Title: Parasitology
    Uncontrolled Keywords: Apoptosis ; Plasmodium ; malaria ; mosquito cysteine proteases.
    Subjects: Q Science > QH Natural history > QH301 Biology
    Departments: Faculty of Health and Medicine > Medicine
    ID Code: 9116
    Deposited By: Dr Karen Grant
    Deposited On: 27 May 2008 13:24
    Refereed?: Yes
    Published?: Published
    Last Modified: 26 Jul 2012 18:32
    Identification Number:
    URI: http://eprints.lancs.ac.uk/id/eprint/9116

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