Liu, Zuifang and Fullwood, Nigel J. and Rimmer, Steve (2000) Synthesis of allyloxycarbonyloxymethyl-5-fluorouracil and copolymerizations with N-vinylpyrrolidinone. Journal of Materials Chemistry, 10 (8). pp. 1771-1775. ISSN 0959-9428
Full text not available from this repository.Abstract
Poly(N-vinylpyrrolidinone)(PNVP) bearing 5-fluorouracil (5-FU) moieties was synthesised via a three-step method. Firstly, 5-FU reacted with formaldehyde to form a mixture of mono- and disubstituted hydroxymethyl-5-FUs. The mixture was then treated with allyl chloroformate to afford allyloxycarbonyloxymethyl-5-FUs. This reaction showed site-specificity: the hydroxymethyl goup at the N-1 position readily reacted with chloroformate whereas the N-3 hydroxymethyl group partially decomposed into formaldehyde and the amide group. 1-Allyloxycarbonyloxymethyl-5-FU ( 4) and NVP were copolymerized in dioxane using azobisisobutyronitrile as an initiator. The monomer reactivity ratios, r 4= 0.32 and rNVP= 0.97, were evaluated by both linear and non-linear methods.
| Item Type: | Article |
|---|---|
| Journal or Publication Title: | Journal of Materials Chemistry |
| Subjects: | Q Science > QH Natural history > QH301 Biology |
| Departments: | Faculty of Science and Technology > Physics Faculty of Health and Medicine > Biomedical & Life Sciences |
| ID Code: | 9097 |
| Deposited By: | Dr Nigel J Fullwood |
| Deposited On: | 23 May 2008 13:38 |
| Refereed?: | Yes |
| Published?: | Published |
| Last Modified: | 26 Jul 2012 18:31 |
| Identification Number: | |
| URI: | http://eprints.lancs.ac.uk/id/eprint/9097 |
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