Liu, Zuifang and Fullwood, Nigel J. and Rimmer, Steve (2000) Synthesis of allyloxycarbonyloxymethyl-5-fluorouracil and copolymerizations with N-vinylpyrrolidinone. Journal of Materials Chemistry, 10 (8). pp. 1771-1775. ISSN 0959-9428Full text not available from this repository.
Poly(N-vinylpyrrolidinone)(PNVP) bearing 5-fluorouracil (5-FU) moieties was synthesised via a three-step method. Firstly, 5-FU reacted with formaldehyde to form a mixture of mono- and disubstituted hydroxymethyl-5-FUs. The mixture was then treated with allyl chloroformate to afford allyloxycarbonyloxymethyl-5-FUs. This reaction showed site-specificity: the hydroxymethyl goup at the N-1 position readily reacted with chloroformate whereas the N-3 hydroxymethyl group partially decomposed into formaldehyde and the amide group. 1-Allyloxycarbonyloxymethyl-5-FU ( 4) and NVP were copolymerized in dioxane using azobisisobutyronitrile as an initiator. The monomer reactivity ratios, r 4= 0.32 and rNVP= 0.97, were evaluated by both linear and non-linear methods.
|Journal or Publication Title:||Journal of Materials Chemistry|
|Subjects:||Q Science > QH Natural history > QH301 Biology|
|Departments:||Faculty of Science and Technology > Physics|
Faculty of Health and Medicine > Biomedical & Life Sciences
|Deposited By:||Dr Nigel J Fullwood|
|Deposited On:||23 May 2008 13:38|
|Last Modified:||26 Jul 2012 18:31|
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