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Synthesis and properties of amphiphilic networks 3 : preparation and characterisation of block conetworks of poly(butyl methacrylate-block-(2,3 propandiol-1-methacrylate-stat-ethandiol dimethacrylate)).

Rimmer, S. and German, Matthew J. and Maughan, J. and Sun, Y. and Fullwood, Nigel J. and Ebdon, J. and Macneil, S. (2005) Synthesis and properties of amphiphilic networks 3 : preparation and characterisation of block conetworks of poly(butyl methacrylate-block-(2,3 propandiol-1-methacrylate-stat-ethandiol dimethacrylate)). Biomaterials, 26 (15). pp. 2219-2230. ISSN 0142-9612

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Abstract

Amphiphilic conetwork polymers were prepared and studied as substrates in the culture of dermal fibroblasts. Both block and random conetworks polymers were produced by radical polymerization of either low-molecular weight monomers or oligomeric macromonomers. The oligomeric macromonomers were prepared by methacrylation of biscarboxy oligo(butyl methacrylates) (OBMA). The latter were synthesized by ozononolysis of poly(butyl methacrylate-co-butadiene) materials. The hydrophilic component was derived from copolymerization with 2,3 propandiol-1-methacrylate and cross-linking was provided by inclusion of ethandiol dimethacrylate (EDMA). None of the synthesized materials showed indications of cytotoxicity to human dermal fibroblasts. All of the block conetworks were highly phase separated and possessed pores on the micron length scale. The equilibrium water contents of the latter could be controlled by addition of EDMA. Block conetworks that did not contain EDMA were highly swollen and had smoother surfaces than those that contained EDMA. The former were poor substrates for cell proliferation (as measured by monitoring DNA content) whilst the latter class gave increasing levels of DNA during culture; an indicator proliferation. The performance of these materials in cell culture was also dependent on the fraction of OBMA in the formulation. Increasing the fractions of BMA, either in the random terpolymer or block networks, system had the effect of increasing both cell proliferation and viability (as measured by the Alamar Blue assay).

Item Type: Article
Journal or Publication Title: Biomaterials
Uncontrolled Keywords: Ampiphilic network ; Hydrogel ; Fibroblast ; Cell proliferation ; Methacrylate
Subjects: Q Science > QH Natural history > QH301 Biology
Departments: Faculty of Science and Technology > Physics
Faculty of Health and Medicine > Health Research
Faculty of Health and Medicine > Biomedical & Life Sciences
ID Code: 9076
Deposited By: Dr Nigel J Fullwood
Deposited On: 23 May 2008 13:54
Refereed?: Yes
Published?: Published
Last Modified: 26 Jul 2012 18:31
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/9076

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