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A microsatellite polymorphism in the gamma interferon gene is associated with resistance to gastrointestinal nematodes in a naturally-parasitised population of Soay sheep.

Coltman, D. and Wilson, Kenneth and Pilkington, J. G. and Stear, M. J. and Pemberton, J. M. (2001) A microsatellite polymorphism in the gamma interferon gene is associated with resistance to gastrointestinal nematodes in a naturally-parasitised population of Soay sheep. Parasitology, 122 (5). pp. 571-582. ISSN 0031-1820

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    Abstract

    Free-living Soay sheep (Ovis aries) on the island of Hirta, St Kilda, Scotland, are naturally parasitized by gastrointestinal nematodes, predominantly Teladorsagia circumcincta. In this paper we show that reduced faecal egg counts (FEC) are associated with an allele at a microsatellite locus located in the first intron of the interferon gamma gene (o(IFN)-γ) in Soay sheep lambs and yearlings, measured at approximately 4 and 16 months of age, respectively. The same allele was also associated with increased T. circumcincta-specific antibody (IgA) in lambs, but not associated significantly in yearlings. Flanking control markers failed to show a significant association with either FEC or IgA. These results suggest that a polymorphic gene conferring increased resistance to gastrointestinal nematode parasites is located at or near the interferon gamma gene, and support previous reports which have mapped a quantitative trait locus (QTL) for resistance to this region in domestic sheep. Our data are consistent with the idea that a functional polymorphism leading to reduced expression or efficacy of (IFN)-γ could enhance the immune response to gastrointestinal nematodes by favouring the activity of the Th2 cell subset and antibody associated immune mechanisms.

    Item Type: Article
    Journal or Publication Title: Parasitology
    Additional Information: The final, definitive version of this article has been published in the Journal, Parasitology, 122 (5), 2001, © Cambridge University Press, 2001.
    Uncontrolled Keywords: cytokine ; helminth ; immunity ; Ovis aries ; parasite.
    Subjects: Q Science > QH Natural history > QH301 Biology
    Departments: Faculty of Science and Technology > Lancaster Environment Centre
    ID Code: 9012
    Deposited By: Dr Kenneth Wilson
    Deposited On: 21 May 2008 14:07
    Refereed?: Yes
    Published?: Published
    Last Modified: 26 Jul 2012 18:30
    Identification Number:
    URI: http://eprints.lancs.ac.uk/id/eprint/9012

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