Lancaster EPrints

Exercise Metabolism in Nonobese Patients with Type 2 Diabetes Following the Acute Restoration of Normoglycaemia

Gaffney, Christopher J and Mansell, Peter and Stephens, Francis B and Macdonald, Ian A and Tsintzas, Kostas (2017) Exercise Metabolism in Nonobese Patients with Type 2 Diabetes Following the Acute Restoration of Normoglycaemia. Journal of Diabetes Research, 2017. ISSN 2314-6753

Full text not available from this repository.

Abstract

This study investigated how acute restoration of normoglycaemia affected energy metabolism during exercise in nonobese patients with type 2 diabetes. Six subjects (mean ± SEM) aged 56.2 ± 2.7 years, with a BMI of 24.5 ± 1.5 kg/m2 and a VO2 peak of 28.7 ml/kg/min, attended the lab on two randomised occasions for a four-hour resting infusion of insulin or saline, followed by 30 minutes cycling at 50% VO2 peak. During the 4 h resting infusion, there was a greater (P < 0.0001) reduction in blood glucose in insulin treatment (INS) (from 11.2 ± 0.6 to 5.6 ± 0.1 mmol/l) than in saline treatment/control (CON) (from 11.5 ± 0.7 to 8.5 ± 0.6 mmol/l). This was associated with a lower (P < 0.05) resting metabolic rate in INS (3.87 ± 0.17) than in CON (4.39 ± 0.30 kJ/min). During subsequent exercise, blood glucose increased significantly in INS from 5.6 ± 0.1 at 0 min to 6.3 ± 0.3 mmol/l at 30 min (P < 0.01), which was accompanied by a lower blood lactate response (P < 0.05). Oxygen uptake, rates of substrate utilization, heart rate, and ratings of perceived exertion were not different between trials. Insulin-induced normoglycaemia increased blood glucose during subsequent exercise without altering overall substrate utilization.

Item Type: Journal Article
Journal or Publication Title: Journal of Diabetes Research
Additional Information: Copyright © 2017 Christopher J. Gaffney et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Subjects: ?? JOURNAL ARTICLE ??
Departments: Faculty of Health and Medicine > Medicine
ID Code: 89472
Deposited By: ep_importer_pure
Deposited On: 05 Jan 2018 16:12
Refereed?: Yes
Published?: Published
Last Modified: 29 Apr 2019 16:44
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/89472

Actions (login required)

View Item