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Novel self-gelling injectable hydrogel/alpha-tricalcium phosphate composites for bone regeneration : Physiochemical and microcomputer tomographical characterization

Douglas, Timothy Edward Lim and Schietse, Josefien and Zima, Aneta and Gorodzha, Svetlana and Parakhonskiy, Bogdan and Khalenkow, Dmitry and Shkarin, Roman and Ivanova, Anna and Baumbach, Tilo and Weinhardt, Venera and Stevens, Christian and Vanhoorne, Valerie and Vervaet, Chris and Balcaen, Lieve and Vanhaecke, Frank and Slosarczyk, Anna and Surmeneva, Maria and Surmenev, Roman and Skirtach, Andre (2018) Novel self-gelling injectable hydrogel/alpha-tricalcium phosphate composites for bone regeneration : Physiochemical and microcomputer tomographical characterization. Journal of Biomedical Materials Research Part A, 106 (3). pp. 822-828. ISSN 1549-3296

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    Abstract

    Mineralized hydrogels are increasingly gaining attention as biomaterials for bone regeneration. The most common mineralization strategy has been addition of preformed inorganic particles during hydrogel formation. This maintains injectability. One common form of bone cement is formed by mixing particles of the highly reactive calcium phosphate alpha-tricalcium phosphate (α-TCP) with water to form hydroxyapatite (HA). The calcium ions released during this reaction can be exploited to crosslink anionic, calcium-binding polymers such as the polysaccharide gellan gum (GG) to induce hydrogel formation. In this study, three different amounts of α-TCP particles were added to GG polymer solution to generate novel, injectable hydrogel-inorganic composites. Distribution of the inorganic phase in the hydrogel was studied by high resolution microcomputer tomography (µCT). Gelation occurred within 30 min. α-TCP converted to HA. µCT revealed inhomogeneous distribution of the inorganic phase in the composites. These results demonstrate the potential of the composites as alternatives to traditional α-TCP bone cement and pave the way for incorporation of biologically active substances and in vitro and in vivo testing.

    Item Type: Journal Article
    Journal or Publication Title: Journal of Biomedical Materials Research Part A
    Additional Information: This is the peer reviewed version of the following article: Douglas TEL, Schietse J, Zima A, Gorodzha S, Parakhonskiy BV, KhaleNkow D, Shkarin R, Ivanova A, Baumbach T, Weinhardt V, Stevens CV, Vanhoorne V, Vervaet C, Balcaen L, Vanhaecke F, Slośarczyk A, Surmeneva MA, Surmenev RA, Skirtach AG. 2018. Novel self-gelling injectable hydrogel/alpha-tricalcium phosphate composites for bone regeneration: Physiochemical and microcomputer tomographical characterization. J Biomed Mater Res Part A 2018:106A:822–828 which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1002/jbm.a.36277/abstract This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.
    Uncontrolled Keywords: hydrogel ; composite ; micro-CT ; gellan gum ; bone cement
    Subjects:
    Departments: Faculty of Science and Technology > Engineering
    ID Code: 89463
    Deposited By: ep_importer_pure
    Deposited On: 05 Jan 2018 13:34
    Refereed?: Yes
    Published?: Published
    Last Modified: 18 Sep 2018 06:08
    Identification Number:
    URI: http://eprints.lancs.ac.uk/id/eprint/89463

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