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Induction of cellular oxidative stress by the β-amyloid peptide involved in Alzheimer's disease.

Gibson, G. L. and Allsop, David and Austen, B. M. (2004) Induction of cellular oxidative stress by the β-amyloid peptide involved in Alzheimer's disease. Protein and Peptide Letters, 11 (3). pp. 257-270. ISSN 0929-8665

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Abstract

β-amyloid, the 39-43 amino acid peptide fragment originating from amyloid precursor protein, is today, generally accepted as the biological entity responsible for causing the debilitating human disorder Alzheimer's disease. Understanding the exact biological effects of β-amyloid in vitro and in vivo is clearly important to provide therapeutic strategies for the disease. Recent in vitro studies have focused on the production of reactive oxygen species by aggregating β- amyloid, but the cellular effects of β-amyloid induced reactive oxygen species production have not been fully elucidated.

Item Type: Article
Journal or Publication Title: Protein and Peptide Letters
Subjects: Q Science > QH Natural history > QH301 Biology
Departments: Faculty of Science and Technology > Lancaster Environment Centre
Faculty of Health and Medicine > Biomedical & Life Sciences
ID Code: 8877
Deposited By: Prof David Allsop
Deposited On: 15 May 2008 14:06
Refereed?: Yes
Published?: Published
Last Modified: 09 Apr 2014 22:15
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/8877

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