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Protein aggregation, metals and oxidative stress in neurodegenerative diseases.

Tabner, Brian J. and El-Agnaf, Omar M. A. and German, M. J. and Fullwood, Nigel J. and Allsop, David (2005) Protein aggregation, metals and oxidative stress in neurodegenerative diseases. Biochemical Society Transactions, 33 (5). pp. 1082-1086. ISSN 0300-5127

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Abstract

There is clear evidence implicating oxidative stress in the pathology of many different neurodegenerative diseases. ROS (reactive oxygen species) are the primary mediators of oxidative stress and many of the aggregating proteins and peptides associated with neurodegenerative disease can generate hydrogen peroxide, a key ROS, apparently through interactions with redox-active metal ions. Our recent results suggest that ROS are generated during the very early stages of protein aggregation, when protofibrils or soluble oligomers are present, but in the absence of mature amyloid fibrils. The generation of ROS during early-stage protein aggregation may be a common, fundamental molecular mechanism underlying the pathogenesis of oxidative damage, neurodegeneration and cell death in several different neurodegenerative diseases. Drugs that specifically target this process could be useful in the future therapy of these diseases.

Item Type: Article
Journal or Publication Title: Biochemical Society Transactions
Uncontrolled Keywords: amyloid ; hydrogen peroxide ; metal ; neurodegeneration ; oligomer ; oxidative stress. ; humans ; neurotoxins ; proteins
Subjects: Q Science > QH Natural history > QH301 Biology
Departments: Faculty of Science and Technology > Lancaster Environment Centre
Faculty of Health and Medicine > Health Research
Faculty of Health and Medicine > Biomedical & Life Sciences
ID Code: 8876
Deposited By: Prof David Allsop
Deposited On: 15 May 2008 14:06
Refereed?: Yes
Published?: Published
Last Modified: 26 Jul 2012 18:28
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/8876

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