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A short synthesis of the β-amyloid (Aβ) aggregation inhibitor 3-p-toluoyl-2-[4′-(3-diethylaminopropoxy)-phenyl]-benzofuran.

Twyman, Lance J. and Allsop, David (1999) A short synthesis of the β-amyloid (Aβ) aggregation inhibitor 3-p-toluoyl-2-[4′-(3-diethylaminopropoxy)-phenyl]-benzofuran. Tetrahedron Letters, 40 (52). pp. 9383-9384. ISSN 0040-4039

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Abstract

A short and convenient synthesis of 3-p-toluoyl-2-[4′-(3-diethylaminopropoxy)-phenyl]-benzofuran, an inhibitor of the aggregation of β-amyloid, which is thought to be the underlying cause of Alzheimer's disease, is described. A short and convenient synthesis of 3-p-toluoyl-2-[4′-(3-diethylaminopropoxy)-phenyl]-benzofuran, an inhibitor of the aggregation of β-amyloid protein is described.

Item Type: Article
Journal or Publication Title: Tetrahedron Letters
Uncontrolled Keywords: Benzofurans ; heterocyclic ; intramolecular Wittig reaction ; β-amyloid ; Alzheimer's disease
Subjects: Q Science > QH Natural history > QH301 Biology
Departments: Faculty of Science and Technology > Physics
Faculty of Health and Medicine > Biomedical & Life Sciences
ID Code: 8875
Deposited By: Prof David Allsop
Deposited On: 15 May 2008 11:40
Refereed?: Yes
Published?: Published
Last Modified: 26 Jul 2012 18:28
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/8875

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