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Pick's disease is associated with mutations in the tau gene.

Pickering-Brown, Stuart and Baker, Matt and Yen, Shu-Hui and Liu, Wan-Kyng and Hasegawa, Masato and Cairns, Nigel and Lantos, Peter L. and Rossor, Martin and Iwatsubo, Takeshi and Davies, Yvonne and Allsop, David and Furlong, Rob and Owen, Frank and Hardy, John and David Mann, David and Hutton, Mike (2000) Pick's disease is associated with mutations in the tau gene. Annals of Neurology, 48 (6). pp. 589-867. ISSN 0364-5134

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Abstract

Recently, mutations within the tau gene have been associated with some familial forms of frontotemporal dementia. To investigate whether tau gene mutations are also associated with Pick's disease, we analyzed the tau gene in 30 cases of pathologically confirmed Pick's disease. Two coding mutations were identified in separate cases of Pick's disease. A glycine-to-arginine mutation at codon 389 was detected in 1 case and a lysine-to-threonine mutation at codon 257 was identified in another. Analysis of dephosphorylated tau from the brain of the patient with the codon 389 mutation revealed a prominent band representing tau, with four microtubule-binding domains and no amino terminal inserts. This is in contrast to Pick's disease without any tau gene mutations, which consist of tau with mainly three microtubule-binding domains and only a trace of tau, with four microtubule-binding domains. Functional analysis of tau with these two mutations demonstrated a reduced ability of tau to promote microtubule assembly. Surprisingly, these mutations increased tau's susceptibility to calpain I digestion, suggesting that this feature may be related to the formation of a Pick type of histology. Moreover, these data suggest that Pick's disease is not a separate entity but part of the frontotemporal dementia disease spectrum.

Item Type: Article
Journal or Publication Title: Annals of Neurology
Subjects: Q Science > QH Natural history > QH301 Biology
Departments: Faculty of Science and Technology > Lancaster Environment Centre
Faculty of Health and Medicine > Biomedical & Life Sciences
ID Code: 8872
Deposited By: Prof David Allsop
Deposited On: 15 May 2008 11:41
Refereed?: Yes
Published?: Published
Last Modified: 26 Jul 2012 18:27
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/8872

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