Allsop, David and Gibson, Gillian and Martin, Ian K. and Moore, Susan and Turnbull, Stuart and Twyman, Lance J. (2001) 3-p-toluoyl-2-[4′-(3-diethylaminopropoxy)-phenyl]-benzofuran and 2-[4′-(3-diethylaminopropoxy)-phenyl]-benzofuran do not act as surfactants or micelles when inhibiting the aggregation of β-amyloid peptide. Bioorganic & Medicinal Chemistry Letters, 11 (2). pp. 255-257. ISSN 0960-894X
Full text not available from this repository.Abstract
The cmc and IC50 values of the β-amyloid (Aβ) aggregation inhibitors, 3-p-toluoyl-2-[4′-(3-diethylaminopropoxy)-phenyl]-benzofuran 1, and 2-[4′-(3-diethylaminopropoxy)-phenyl]-benzofuran 2 have been determined. After comparison of the cmc data and biological data (IC50 values), we conclude that these active benzofurans do not act as surfactants or micelles at the concentration required to inhibit β-amyloid-peptide aggregation.
| Item Type: | Article |
|---|---|
| Journal or Publication Title: | Bioorganic & Medicinal Chemistry Letters |
| Subjects: | Q Science > QH Natural history > QH301 Biology |
| Departments: | Faculty of Health and Medicine > Biomedical & Life Sciences Faculty of Science and Technology > Lancaster Environment Centre Faculty of Science and Technology > Physics |
| ID Code: | 8860 |
| Deposited By: | Prof David Allsop |
| Deposited On: | 15 May 2008 11:43 |
| Refereed?: | Yes |
| Published?: | Published |
| Last Modified: | 26 Jul 2012 18:27 |
| Identification Number: | |
| URI: | http://eprints.lancs.ac.uk/id/eprint/8860 |
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