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Quinacrine acts as an antioxidant and reduces the toxicity of the prion peptide PrP106-126.

Turnbull, Stuart and Tabner, Brian J. and Brown, David R. and Allsop, David (2003) Quinacrine acts as an antioxidant and reduces the toxicity of the prion peptide PrP106-126. Neuroreport, 14 (13). pp. 1743-1745.

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Abstract

The accumulation of protein aggregates in the brain is a central feature of several different neurodegenerative diseases. We have recently shown that A[beta] and [alpha]-synuclein, associated with Alzheimer's disease, Parkinson's disease and related disorders, can both induce the formation of hydroxyl radicals following incubation in solution, upon addition of Fe(II). PrP106-126, a model peptide for the study of prion protein-mediated cell death, shares the same property. In this study we show that quinacrine (an anti-malarial drug and inhibitor of prion replication) acts as an effective antioxidant, readily scavenging hydroxyl radicals formed from hydrogen peroxide via the Fenton reaction or generated during incubation of the PrP106-126 peptide. Furthermore, the toxicity of PrP106-126 to cultured cells was significantly inhibited by quinacrine.

Item Type: Article
Journal or Publication Title: Neuroreport
Subjects: Q Science > QH Natural history > QH301 Biology
Departments: Faculty of Science and Technology > Lancaster Environment Centre
Faculty of Health and Medicine > Biomedical & Life Sciences
ID Code: 8854
Deposited By: Prof David Allsop
Deposited On: 15 May 2008 11:44
Refereed?: Yes
Published?: Published
Last Modified: 09 Apr 2014 22:14
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/8854

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