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Copper-dependent generation of hydrogen peroxide from the toxic prion protein fragment PrP106-126.

Turnbull, Stuart and Tabner, Brian J. and Brown, David R. and Allsop, David (2003) Copper-dependent generation of hydrogen peroxide from the toxic prion protein fragment PrP106-126. Neuroscience Letters, 336 (3). pp. 159-162. ISSN 0304-3940

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Abstract

Oligomeric forms of many of the aggregating proteins associated with neurodegenerative diseases are toxic to cultured cells. We have shown recently that Aβ and -synuclein can both induce the formation of hydroxyl radicals following incubation in solution, upon the addition of Fe(II). Thus, they appear to generate hydrogen peroxide, which is converted to hydroxyl radicals via the Fenton reaction. Here we show that the widely studied toxic peptide fragment of the prion protein, PrP106–126, has exactly the same property, but only in the presence of copper ions. Since the aggregation and toxicity of PrP106–126 have been reported to be critically dependent on copper binding, our data suggest that the published cytotoxic effects of this peptide could also be due to its ability to generate hydrogen peroxide.

Item Type: Article
Journal or Publication Title: Neuroscience Letters
Uncontrolled Keywords: Copper ; Free radicals ; Hydrogen peroxide ; Oxidative stress ; Prion protein
Subjects: Q Science > Q Science (General)
Departments: Faculty of Science and Technology > Lancaster Environment Centre
Faculty of Health and Medicine > Biomedical & Life Sciences
ID Code: 8852
Deposited By: Prof David Allsop
Deposited On: 15 May 2008 11:44
Refereed?: Yes
Published?: Published
Last Modified: 26 Jul 2012 18:27
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/8852

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