Turnbull, Stuart and Tabner, Brian J. and Brown, David R. and Allsop, David (2003) Copper-dependent generation of hydrogen peroxide from the toxic prion protein fragment PrP106-126. Neuroscience Letters, 336 (3). pp. 159-162. ISSN 0304-3940Full text not available from this repository.
Oligomeric forms of many of the aggregating proteins associated with neurodegenerative diseases are toxic to cultured cells. We have shown recently that Aβ and -synuclein can both induce the formation of hydroxyl radicals following incubation in solution, upon the addition of Fe(II). Thus, they appear to generate hydrogen peroxide, which is converted to hydroxyl radicals via the Fenton reaction. Here we show that the widely studied toxic peptide fragment of the prion protein, PrP106–126, has exactly the same property, but only in the presence of copper ions. Since the aggregation and toxicity of PrP106–126 have been reported to be critically dependent on copper binding, our data suggest that the published cytotoxic effects of this peptide could also be due to its ability to generate hydrogen peroxide.
|Journal or Publication Title:||Neuroscience Letters|
|Uncontrolled Keywords:||Copper ; Free radicals ; Hydrogen peroxide ; Oxidative stress ; Prion protein|
|Subjects:||Q Science > Q Science (General)|
|Departments:||Faculty of Science and Technology > Lancaster Environment Centre|
Faculty of Health and Medicine > Biomedical & Life Sciences
|Deposited By:||Prof David Allsop|
|Deposited On:||15 May 2008 11:44|
|Last Modified:||07 Jan 2015 16:09|
Actions (login required)