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α-Synuclein and the pathogenesis of Parkinson’s disease.

Martin, Frank and Allsop, David and Williamson, Sally J. M. and Paleologou, Katerina E. and El-Agnaf, Omar M. A. (2004) α-Synuclein and the pathogenesis of Parkinson’s disease. Protein and Peptide Letters, 11 (3). pp. 229-237. ISSN 0929-8665

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Abstract

Lesions known as Lewy bodies (LBs) and Lewy neurites (LNs) characterise brains of Parkinson’s disease (PD) patients. Intracellular aggregation of a-synuclein (a-syn) appears to play a key role in the generation of LBs andLNs. Such aggregation in the presence of redox metals may initiate Fenton reaction-mediated generation of reactive oxygen species (ROS). ROS thus generated may result in cytotoxic mechanisms such as the induction of DNA single-strand breaks.

Item Type: Article
Journal or Publication Title: Protein and Peptide Letters
Subjects: Q Science > QH Natural history > QH301 Biology
Departments: Faculty of Science and Technology > Lancaster Environment Centre
Faculty of Health and Medicine > Biomedical & Life Sciences
ID Code: 8845
Deposited By: Prof David Allsop
Deposited On: 15 May 2008 11:46
Refereed?: Yes
Published?: Published
Last Modified: 09 Apr 2014 22:14
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/8845

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