Martin, Frank and Allsop, David and Williamson, Sally J. M. and Paleologou, Katerina E. and El-Agnaf, Omar M. A. (2004) α-Synuclein and the pathogenesis of Parkinson’s disease. Protein and Peptide Letters, 11 (3). pp. 229-237. ISSN 0929-8665
Full text not available from this repository.Abstract
Lesions known as Lewy bodies (LBs) and Lewy neurites (LNs) characterise brains of Parkinson’s disease (PD) patients. Intracellular aggregation of a-synuclein (a-syn) appears to play a key role in the generation of LBs andLNs. Such aggregation in the presence of redox metals may initiate Fenton reaction-mediated generation of reactive oxygen species (ROS). ROS thus generated may result in cytotoxic mechanisms such as the induction of DNA single-strand breaks.
| Item Type: | Article |
|---|---|
| Journal or Publication Title: | Protein and Peptide Letters |
| Subjects: | Q Science > QH Natural history > QH301 Biology |
| Departments: | Faculty of Science and Technology > Lancaster Environment Centre Faculty of Health and Medicine > Biomedical & Life Sciences |
| ID Code: | 8845 |
| Deposited By: | Prof David Allsop |
| Deposited On: | 15 May 2008 11:46 |
| Refereed?: | Yes |
| Published?: | Published |
| Last Modified: | 26 Jul 2012 18:27 |
| Identification Number: | |
| URI: | http://eprints.lancs.ac.uk/id/eprint/8845 |
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