Martin, Frank and Allsop, David and Williamson, Sally J. M. and Paleologou, Katerina E. and El-Agnaf, Omar M. A. (2004) α-Synuclein and the pathogenesis of Parkinson’s disease. Protein and Peptide Letters, 11 (3). pp. 229-237. ISSN 0929-8665Full text not available from this repository.
Lesions known as Lewy bodies (LBs) and Lewy neurites (LNs) characterise brains of Parkinson’s disease (PD) patients. Intracellular aggregation of a-synuclein (a-syn) appears to play a key role in the generation of LBs andLNs. Such aggregation in the presence of redox metals may initiate Fenton reaction-mediated generation of reactive oxygen species (ROS). ROS thus generated may result in cytotoxic mechanisms such as the induction of DNA single-strand breaks.
|Journal or Publication Title:||Protein and Peptide Letters|
|Subjects:||Q Science > QH Natural history > QH301 Biology|
|Departments:||Faculty of Science and Technology > Lancaster Environment Centre|
Faculty of Health and Medicine > Biomedical & Life Sciences
|Deposited By:||Prof David Allsop|
|Deposited On:||15 May 2008 11:46|
|Last Modified:||07 Jan 2015 16:09|
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