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Decreased α-synuclein in cerebrospinal fluid of aged individuals and subjects with Parkinson’s disease.

Tokuda, Takahiko and Salem, Sultan A. and Allsop, David and Mizuno, Toshiki and Nakagawa, Masanori and Qureshi, Mohamed M. and Locascio, Joseph J. and Schlossmacher, Michael G. and El-Agnaf, Omar (2006) Decreased α-synuclein in cerebrospinal fluid of aged individuals and subjects with Parkinson’s disease. Biochemical and Biophysical Research Communications, 349 (1). pp. 162-166. ISSN 0006-291X

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Abstract

There is ample biochemical, pathological, and genetic evidence that the metabolism of -synuclein (-syn) plays a crucial role in the pathogenesis of Parkinson disease (PD). To examine whether quantification of -syn in cerebrospinal fluid (CSF) is potentially informative in the diagnosis of PD, we developed a specific ELISA system and measured the concentration of -syn in CSF from 33 patients with PD (diagnosed according to UK PD Society Brain Bank criteria) and 38 control subjects including 9 neurologically healthy individuals. We found that PD patients had significantly lower -syn levels in their CSF than the control groups (p < 0.0001) even after adjusting for gender and age. Age was independently associated with lower -syn levels. Logistic regression analysis showed that reduction in CSF -syn served as a significant predictor of PD beyond age and gender alone (area under ROC curve, c = 0.882). Furthermore, we observed a close inverse correlation between -syn levels in CSF and assigned Hoehn and Yahr score in this cohort of 71 living subjects (p < 0.0001), even after adjusting for age. These findings identify in the quantification of -syn from CSF a potential laboratory marker to aid the clinical diagnosis of PD.

Item Type: Article
Journal or Publication Title: Biochemical and Biophysical Research Communications
Uncontrolled Keywords: Parkinson disease ; Neurodegenerative diseases ; -Synuclein ; Cerebrospinal fluid ; ELISA ; Biomarker ; Diagnosis
Subjects: Q Science > QH Natural history > QH301 Biology
Departments: Faculty of Science and Technology > Lancaster Environment Centre
Faculty of Health and Medicine > Biomedical & Life Sciences
ID Code: 8840
Deposited By: Prof David Allsop
Deposited On: 15 May 2008 11:47
Refereed?: Yes
Published?: Published
Last Modified: 26 Jul 2012 18:27
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/8840

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