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Mutation Induction by Ionizing Radiation in Three Human Bladder Tumour Cell Lines.

Kent, C. R. H. and Edwards, S. and McMillan, T. J. (1993) Mutation Induction by Ionizing Radiation in Three Human Bladder Tumour Cell Lines. International Journal of Radiation Biology, 63 (1). pp. 1-5. ISSN 1362-3095

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Abstract

Mutation induction at the hypoxanthine-guanine phosphoribosyl transferase (hprt) locus has been studied in three human bladder tumour cell lines of varying radiosensitivity. U1-S40b, a radiosensitive mutant clone of MGH-U1, has been previously reported to show no difference in split-dose recovery or low dose-rate sparing, but to have an impaired repair fidelity when compared to its parent line. In this paper we have shown that U1-S40b is less mutable at the hprt locus at a similar level of survival. This may represent an increased incidence of severe or non-repairable lesions, making hprt- mutants poorly recoverable in U1-S40b when compared to MGH-U1. No difference was seen in mutation induction between MGH-U1 and RT112, another human bladder tumour cell line of similar radiosensitivity to MGH-U1.

Item Type: Article
Journal or Publication Title: International Journal of Radiation Biology
Subjects: Q Science > QH Natural history > QH301 Biology
Departments: Faculty of Science and Technology > Lancaster Environment Centre
VC's Office
ID Code: 8760
Deposited By: Professor Trevor McMillan
Deposited On: 12 May 2008 16:07
Refereed?: Yes
Published?: Published
Last Modified: 26 Jul 2012 18:26
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/8760

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