Kent, C. R. H. and Edwards, S. and McMillan, T. J. (1993) Mutation Induction by Ionizing Radiation in Three Human Bladder Tumour Cell Lines. International Journal of Radiation Biology, 63 (1). pp. 1-5. ISSN 1362-3095
Full text not available from this repository.Abstract
Mutation induction at the hypoxanthine-guanine phosphoribosyl transferase (hprt) locus has been studied in three human bladder tumour cell lines of varying radiosensitivity. U1-S40b, a radiosensitive mutant clone of MGH-U1, has been previously reported to show no difference in split-dose recovery or low dose-rate sparing, but to have an impaired repair fidelity when compared to its parent line. In this paper we have shown that U1-S40b is less mutable at the hprt locus at a similar level of survival. This may represent an increased incidence of severe or non-repairable lesions, making hprt- mutants poorly recoverable in U1-S40b when compared to MGH-U1. No difference was seen in mutation induction between MGH-U1 and RT112, another human bladder tumour cell line of similar radiosensitivity to MGH-U1.
| Item Type: | Article |
|---|---|
| Journal or Publication Title: | International Journal of Radiation Biology |
| Subjects: | Q Science > QH Natural history > QH301 Biology |
| Departments: | Faculty of Science and Technology > Lancaster Environment Centre VC's Office |
| ID Code: | 8760 |
| Deposited By: | Professor Trevor McMillan |
| Deposited On: | 12 May 2008 16:07 |
| Refereed?: | Yes |
| Published?: | Published |
| Last Modified: | 26 Jul 2012 18:26 |
| Identification Number: | |
| URI: | http://eprints.lancs.ac.uk/id/eprint/8760 |
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