Mutation Induction by Ionizing Radiation in Three Human Bladder Tumour Cell Lines.

Kent, C. R. H. and Edwards, S. and McMillan, T. J. (1993) Mutation Induction by Ionizing Radiation in Three Human Bladder Tumour Cell Lines. International Journal of Radiation Biology, 63 (1). pp. 1-5. ISSN 0955-3002

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Abstract

Mutation induction at the hypoxanthine-guanine phosphoribosyl transferase (hprt) locus has been studied in three human bladder tumour cell lines of varying radiosensitivity. U1-S40b, a radiosensitive mutant clone of MGH-U1, has been previously reported to show no difference in split-dose recovery or low dose-rate sparing, but to have an impaired repair fidelity when compared to its parent line. In this paper we have shown that U1-S40b is less mutable at the hprt locus at a similar level of survival. This may represent an increased incidence of severe or non-repairable lesions, making hprt- mutants poorly recoverable in U1-S40b when compared to MGH-U1. No difference was seen in mutation induction between MGH-U1 and RT112, another human bladder tumour cell line of similar radiosensitivity to MGH-U1.

Item Type:
Journal Article
Journal or Publication Title:
International Journal of Radiation Biology
Uncontrolled Keywords:
/dk/atira/pure/researchoutput/libraryofcongress/qh301
Subjects:
?? RADIOLOGY NUCLEAR MEDICINE AND IMAGINGRADIOLOGICAL AND ULTRASOUND TECHNOLOGYQH301 BIOLOGY ??
ID Code:
8760
Deposited On:
12 May 2008 15:07
Refereed?:
Yes
Published?:
Published
Last Modified:
21 Sep 2023 00:58