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Structural and physiological neurovascular changes in idiopathic Parkinson's disease and its clinical phenotypes

Al-Bachari, Sarah and Vidyasagar, Rishma and Emsley, Hedley C. A. and Parkes, Laura M (2017) Structural and physiological neurovascular changes in idiopathic Parkinson's disease and its clinical phenotypes. Journal of Cerebral Blood Flow and Metabolism, 37 (10). pp. 3409-3421. ISSN 0271-678X

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    Abstract

    Neurovascular changes are likely to interact importantly with the neurodegenerative process in idiopathic Parkinson's disease (IPD). Markers of neurovascular status (NVS) include white matter lesion (WML) burden and arterial spin labelling (ASL) measurements of cerebral blood flow (CBF) and arterial arrival time (AAT). We investigated NVS in IPD, including an analysis of IPD clinical phenotypes, by comparison with two control groups, one with a history of clinical cerebrovascular disease (CVD) (control positive, CP) and one without CVD (control negative, CN). Fifty-one patients with IPD (mean age 69.0 ± 7.7 years) (21 tremor dominant (TD), 24 postural instability and gait disorder (PIGD) and six intermediates), 18 CP (mean age 70.1 ± 8.0 years) and 34 CN subjects (mean age 67.4 ± 7.6 years) completed a 3T MRI scan protocol including T2-weighted fluid-attenuated inversion recovery (FLAIR) and ASL. IPD patients showed diffuse regions of significantly prolonged AAT, small regions of lower CBF and greater WML burden by comparison with CN subjects. TD patients showed lower WML volume by comparison with PIGD patients. These imaging data thus show altered NVS in IPD, with some evidence for IPD phenotype-specific differences.

    Item Type: Article
    Journal or Publication Title: Journal of Cerebral Blood Flow and Metabolism
    Additional Information: The final, definitive version of this article has been published in the Journal, Journal of Cerebral Blood Flow and Metabolism, 37 (10), 2017, © SAGE Publications Ltd, 2017 by SAGE Publications Ltd at the Journal of Cerebral Blood Flow and Metabolism page: http://journals.sagepub.com/home/jcb on SAGE Journals Online: http://journals.sagepub.com/
    Uncontrolled Keywords: Magnetic resonance imaging ; arterial spin labelling ; cerebral blood flow ; Parkinson’s disease ; cerebrovascular disease
    Subjects:
    Departments: Faculty of Health and Medicine > Medicine
    ID Code: 84800
    Deposited By: ep_importer_pure
    Deposited On: 22 Feb 2017 11:22
    Refereed?: Yes
    Published?: Published
    Last Modified: 24 Nov 2017 01:42
    Identification Number:
    URI: http://eprints.lancs.ac.uk/id/eprint/84800

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