Fearnhead, Paul and Smith, Nick G. C. (2005) A novel method with improved power to detect recombination hotspots from polymorphism data reveals multiple hotspots in human genes. American Journal of Human Genetics, 77 (5). pp. 781-794. ISSN 1537-6605Full text not available from this repository.
We introduce a new method for detection of recombination hotspots from population genetic data. This method is based on (a) defining an (approximate) penalized likelihood for how recombination rate varies with physical position and (b) maximizing this penalized likelihood over possible sets of recombination hotspots. Simulation results suggest that this is a more powerful method for detection of hotspots than are existing methods. We apply the method to data from 89 genes sequenced in African American and European American populations. We find many genes with multiple hotspots, and some hotspots show evidence of being population-specific. Our results suggest that hotspots are randomly positioned within genes and could be as frequent as one per 30 kb.
|Journal or Publication Title:||American Journal of Human Genetics|
|Subjects:||Q Science > QA Mathematics|
|Departments:||Faculty of Science and Technology > Mathematics and Statistics|
|Deposited By:||Prof Paul Fearnhead|
|Deposited On:||15 Apr 2008 11:07|
|Last Modified:||26 Jul 2012 18:21|
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