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Collagen-based scaffold as a delivery system for a niacinamide dominated formulation without loss of resistance against enzymatic degradation

Wessels, Quenton Bester (2016) Collagen-based scaffold as a delivery system for a niacinamide dominated formulation without loss of resistance against enzymatic degradation. International Journal of Biomedical Engineering and Technology, 20 (4). pp. 330-343. ISSN 1752-6418

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Abstract

Exogenous factors aimed at promoting fibroblast activity might hold the key to improving the clinical outcome of chronic wounds. The current study explores the feasibility to use a collagen-based scaffold as a delivery system for a niacinamide dominated formulation in vivo. The combined use of niacinamide, L-carnosine, hesperidin and a HSP70 homologue is known to promote fibroblast activity in vitro. Scaffold mediated wound healing was assessed in 16 female Sprague-Dawley rats that received both a control scaffold and an enhanced scaffold. The test scaffolds presented with a higher fibroblast count (60.49 ± 9.90% of the total cell infiltrate) on day 7 compared that of the control scaffolds (42.62 ± 13.60%) but was found to be statistically insignificant. However, the addition of these active components did not compromise the in vivo resistance against enzymatic degradation nor alter the scaffold microenvironment deleteriously.

Item Type: Article
Journal or Publication Title: International Journal of Biomedical Engineering and Technology
Uncontrolled Keywords: collagen scaffold ; niacinamide ; L-carnosine ; hesperidin ; HSP70 homologue ; enzymatic degradation ; delivery systems ; fibroblast activity ; chronic wounds ; wound healing
Subjects:
Departments: Faculty of Health and Medicine > Medicine
ID Code: 81083
Deposited By: ep_importer_pure
Deposited On: 18 Aug 2016 15:20
Refereed?: Yes
Published?: Published
Last Modified: 18 Dec 2017 08:03
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/81083

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