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DNA pooling analysis of ADHD and genes regulating vesicle release of neurotransmitters

Brookes, Keeley Joanne and Knight, Joanne and Xu, Xunfeng and Asherson, Philip (2005) DNA pooling analysis of ADHD and genes regulating vesicle release of neurotransmitters. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 139B (1). pp. 33-37. ISSN 1552-4841

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Abstract

ADHD is one of the most prevalent, and heritable behavioural disorders in childhood. Genetic associations have been reported with polymorphic variants within or near to dopamine pathway genes. Recently snap-25 has also shown association with ADHD in several datasets. We therefore investigated other genes that produce proteins that interact with SNAP-25 in the mechanism of vesicular release of neurotransmitters at the synapse. A total of 106 SNPs were screened for minor allele frequency greater than 5% and 61 SNPs selected for analysis in DNA pools made up from an ADHD clinical sample of DSM-IV combined type probands (n = 180) and a control sample of 90 males and 90 females. Initial screening identified several SNPs that showed allele frequency differences of 5% or more. One SNP in the synaptophysin gene showed suggestive evidence of association following case-control and TDT analysis and warrants further investigation.

Item Type: Article
Journal or Publication Title: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Additional Information: (c) 2005 Wiley-Liss, Inc.
Uncontrolled Keywords: Attention Deficit Disorder with Hyperactivity ; Cytoplasmic Vesicles ; DNA ; Female ; Gene Frequency ; Gene Pool ; Genetic Markers ; Genetic Predisposition to Disease ; Humans ; Neurotransmitter Agents ; Polymorphism, Single Nucleotide ; Synapses
Subjects:
Departments:
ID Code: 79952
Deposited By: ep_importer_pure
Deposited On: 07 Jun 2016 11:20
Refereed?: Yes
Published?: Published
Last Modified: 21 Sep 2017 01:35
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/79952

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