Human chromosome 17 in essential hypertension

Knight, Jo and Munroe, P. B. and Pembroke, J. C. and Caulfield, M. J. (2003) Human chromosome 17 in essential hypertension. Annals of Human Genetics, 67 (2). pp. 193-206. ISSN 0003-4800

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Abstract

Hypertension affects up to 30% of the adult population in Western societies and is a major risk factor for kidney disease, stroke and coronary heart disease. It is a complex trait thought to be influenced by a number of genes and environmental factors, although the precise aetiology remains unknown at this time. A number of methods have been successfully used to identify mutations that cause Mendelian traits and these are now being applied to the investigation of complex diseases. This review summarises the data gathered, using such approaches, that suggest there is a gene or genes on chromosome 17 causing human essential hypertension. Studies in rodent models are discussed first, followed by studies of human hypertension that include the investigation of pseudohypoaldosteronism type II, a monogenic trait that manifests with hypertension alongside other phenotypic variables. In addition, candidate gene studies, genome screens and linkage studies based on comparative mapping are outlined. To date no gene has been identified on human chromosome 17 that influences blood pressure and causes human essential hypertension. However, results of ongoing fine mapping and candidate gene studies in both rodents and man are eagerly awaited.

Item Type:
Journal Article
Journal or Publication Title:
Annals of Human Genetics
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2700/2716
Subjects:
?? ANIMALSBLOOD PRESSURECHROMOSOME MAPPINGCHROMOSOMES, HUMAN, PAIR 17DISEASE MODELS, ANIMALGENETIC LINKAGEGENETIC MARKERSHUMANSHYPERTENSIONMICEPEPTIDYL-DIPEPTIDASE APHENOTYPEPSEUDOHYPOALDOSTERONISMQUANTITATIVE TRAIT LOCIRATSRATS, INBRED SHRGENETICSGENETICS(C ??
ID Code:
79897
Deposited By:
Deposited On:
07 Jun 2016 15:56
Refereed?:
Yes
Published?:
Published
Last Modified:
17 Sep 2023 01:52