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Computational modeling of single-cell migration: the leading role of extracellular matrix fibers

Schlueter, Daniela K. and Ramis-Conde, Ignacio and Chaplain, Mark A. J. (2012) Computational modeling of single-cell migration: the leading role of extracellular matrix fibers. Biophysical Journal, 103 (6). pp. 1141-1151. ISSN 0006-3495

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    Abstract

    Cell migration is vitally important in a wide variety of biological contexts ranging from embryonic development and wound healing to malignant diseases such as cancer. It is a very complex process that is controlled by intracellular signaling pathways as well as the cell's microenvironment. Due to its importance and complexity, it has been studied for many years in the biomedical sciences, and in the last 30 years it also received an increasing amount of interest from theoretical scientists and mathematical modelers. Here we propose a force-based, individual-based modeling framework that links single-cell migration with matrix fibers and cell-matrix interactions through contact guidance and matrix remodelling. With this approach, we can highlight the effect of the cell's environment on its migration. We investigate the influence of matrix stiffness, matrix architecture, and cell speed on migration using quantitative measures that allow us to compare the results to experiments.

    Item Type: Journal Article
    Journal or Publication Title: Biophysical Journal
    Additional Information: This is an Open Access article distributed under the terms of the Creative Commons-Attribution Noncommercial License (http://creativecommons. org/licenses/by-nc/2.0/), which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
    Subjects:
    Departments: Faculty of Health and Medicine > Medicine
    ID Code: 76431
    Deposited By: ep_importer_pure
    Deposited On: 30 Oct 2015 11:24
    Refereed?: Yes
    Published?: Published
    Last Modified: 21 Aug 2018 00:41
    Identification Number:
    URI: http://eprints.lancs.ac.uk/id/eprint/76431

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