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The use of DNA double strand break quantification in radiotherapy.

McMillan, Trevor J. and Tobi, S. and Mateos, S. and Lemon, C. (2001) The use of DNA double strand break quantification in radiotherapy. International Journal Radiation Oncology Biology Physics, 49 (2). pp. 373-377.

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Abstract

DNA double-strand breaks (DSB) are an important direct consequence of treating cells with ionizingradiation. A variety of evidence points toward DSBs being the key damage type linked to radiation-induced lethality. In particular, the link between DSB and chromosome breakage, which in turn closely correlates with cell death in some cell types, is strongly supportive of this concept. There has been much interest in the possibility of using measures of strand breaks as a pretreatment test of radiation response. This has largely been in the context of assessing inherent cellular sensitivity through damage induction or repair parameters. A number of studies have produced hopeful results, but overall there has been no parameter that can reliably predict radiosensitivity. This may be due to the inadequacies of the assays, but it is more likely to reflect the fact that the radiosensitivity of cells is dictated by a whole series of events; alterations in many of these can alter the overall response. In addition, it is now recognized that cell-signalling pathways form an essential part of the cellular response to damage, and these can be triggered by damage other than DSB. It is therefore possible that while DSBs are clearly important—and they may be the single most important lesion in some types—other damage types may be significant triggers of cell death pathways after ionizing radiation treatment.

Item Type: Article
Journal or Publication Title: International Journal Radiation Oncology Biology Physics
Additional Information: The final, definitive version of this article has been published in the Journal, International Journal Radiation Oncology Biology Physics, 49 (2), 2001, © ELSEVIER.
Uncontrolled Keywords: Radiation ; Double-strand break ; Repair ; Damage
Subjects: Q Science > QH Natural history > QH301 Biology
Departments: Faculty of Science and Technology > Lancaster Environment Centre
VC's Office
ID Code: 72
Deposited By: Professor Trevor McMillan
Deposited On: 30 May 2007
Refereed?: Yes
Published?: Published
Last Modified: 26 Jul 2012 18:19
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/72

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