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Assignment of the gene for dyskeratosis congenita to Xq28

Connor, J. M. and Gatherer, D. and Gray, F. C. and Pirrit, L. A. and Affara, N. A. (1986) Assignment of the gene for dyskeratosis congenita to Xq28. Human Genetics, 72 (4). pp. 348-351. ISSN 0340-6717

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Abstract

Dyskeratosis congenita is an X-linked recessive disorder with diagnostic dermatological features, bone marrow hypofunction, and a predisposition to neoplasia in early adult life. Linkage analysis was undertaken in an extensive family with the condition using the Xg blood group and 17 cloned X chromosomal DNA sequences which recognise restriction fragment length polymorphisms (RFLPs). No recombination was observed between the locus for dyskeratosis congenita (DKC) and the RFLPs identified by DXS52 (St14-1) (Zmax = 3.33 at theta max = 0 with 95% confidence limits of 0 to 14cM). Similarly no recombination was observed for the disease locus and F8 (Zmax = 1.23 at theta max = 0) nor for DXS15 (Zmax = 1.62 at theta max = 0), but both of these markers were only informative in part of the family whereas DXS52 was fully informative. DXS52, DXS15, and F8 are known to be tightly linked and have previously been assigned to Xq28. Thus the gene for dyskeratosis congenita can be assigned to Xq28. These DNA sequence polymorphisms will be of clinical value for carrier detection and prenatal diagnosis.

Item Type: Article
Journal or Publication Title: Human Genetics
Uncontrolled Keywords: Adolescent ; Adult ; Child ; Chromosome Mapping ; DNA Restriction Enzymes ; Female ; Genes, Recessive ; Genetic Linkage ; Genetic Markers ; Humans ; Male ; Middle Aged ; Pedigree ; Pigmentation Disorders ; Skin Diseases ; X Chromosome
Subjects:
Departments: Faculty of Health and Medicine > Biomedical & Life Sciences
ID Code: 68714
Deposited By: ep_importer_pure
Deposited On: 25 Feb 2014 09:41
Refereed?: Yes
Published?: Published
Last Modified: 16 Oct 2017 06:32
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/68714

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