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Transforming growth factor betas in mammalian embryogenesis

Akhurst, Rosemary J. and FitzPatrick, David R. and Gatherer, Derek and Lehnert, Sigrd A. and Millan, Fergus A. (1990) Transforming growth factor betas in mammalian embryogenesis. Progress in Growth Factor Research, 2 (3). pp. 153-168. ISSN 0955-2235

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Type beta transforming growth factors (TGF beta s) are members of a large superfamily of related proteins, each of which plays a pivotal role in embryonic processes. The TGF beta s per se are at least five in number, though only three isoforms have been identified in mammals. Here we will review the evidence, taken from in vitro studies on bioactivity and histochemical localization of RNAs and encoded proteins in vivo, that TGF beta 1, beta 2 and beta 3 are involved in several mammalian developmental processes, including control of growth, differentiation, tissue inductions and morphogenesis.

Item Type: Journal Article
Journal or Publication Title: Progress in Growth Factor Research
Uncontrolled Keywords: Animals ; Blastocyst ; Bone Development ; Cardiovascular System ; Embryonic and Fetal Development ; Epithelium ; Hematopoiesis ; Transforming Growth Factor beta
Departments: Faculty of Health and Medicine > Biomedical & Life Sciences
ID Code: 66889
Deposited By: ep_importer_pure
Deposited On: 30 Sep 2013 16:27
Refereed?: Yes
Published?: Published
Last Modified: 11 Apr 2018 01:11
Identification Number:

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