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Patterns of divergence in the vCXCL and vGPCR gene clusters in primate cytomegalovirus genomes

Alcendor, Donald J and Zong, Jianchao and Dolan, Aidan and Gatherer, Derek and Davison, Andrew J. and Hayward, Gary S. (2009) Patterns of divergence in the vCXCL and vGPCR gene clusters in primate cytomegalovirus genomes. Virology, 395 (1). pp. 21-32. ISSN 0042-6822

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Abstract

Primate cytomegalovirus (CMV) genomes contain tandemly repeated gene clusters putatively encoding divergent CXC chemokine ligand-like proteins (vCXCLs) and G protein-coupled receptor-like proteins (vGPCRs). In human, chimpanzee and rhesus CMVs, respectively, the vCXCL cluster contains two, three and six genes, and the vGPCR cluster contains two, two and five genes. We report that (i) green monkey CMV strains fall into two groups, containing either eight and five genes or seven and six genes in the respective clusters, and (ii) owl monkey CMV has two and zero genes. Phylogenetic analysis suggested that the vCXCL cluster evolved from a CXCL chemokine gene (probably GRO-alpha) that was captured in an incompletely spliced form by an ancestor of Old and New World primate CMVs, and that the vGPCR cluster evolved from a GPCR gene captured by an Old World primate CMV. Both clusters appear to have evolved via complex duplication and deletion events.

Item Type: Article
Journal or Publication Title: Virology
Uncontrolled Keywords: Amino Acid Sequence ; Animals ; Cell Line ; Chemokines, CXC ; Cytomegalovirus ; Evolution, Molecular ; Gene Duplication ; Genes, Viral ; Genome, Viral ; Humans ; Molecular Sequence Data ; Multigene Family ; Phylogeny ; Primates ; Receptors, G-Protein-Coupled ; Sequence Alignment
Subjects:
Departments: Faculty of Health and Medicine > Biomedical & Life Sciences
ID Code: 66881
Deposited By: ep_importer_pure
Deposited On: 30 Sep 2013 16:04
Refereed?: Yes
Published?: Published
Last Modified: 21 Sep 2017 05:49
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/66881

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