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Small regions of preferential codon usage and their effect on overall codon bias:the case of the plp gene

Gatherer, Derek and McEwan, Neil R. (1997) Small regions of preferential codon usage and their effect on overall codon bias:the case of the plp gene. Biochemistry and Molecular Biology International, 43 (1). pp. 107-114. ISSN 1039-9712

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Abstract

Preferential codon usage within synonymous groups (codon bias), is hypothesised to be a consequence of either mutational pressure or translational selection. This paper examines PLP and DM-20, two transcripts differentially spliced from the pip gene, using a variety of previously described indices measuring codon bias as well as a novel index for quantifying the response to directional mutation pressure. The results demonstrate that small regions of extreme codon bias may have appreciable effects on the quantification of total bias, and that this effect may be either an increase or a decrease depending which index is used.

Item Type: Article
Journal or Publication Title: Biochemistry and Molecular Biology International
Uncontrolled Keywords: MYELIN PROTEOLIPID PROTEIN ; TRANSLATIONAL SELECTION ; MESSENGER-RNA ; JIMPY MUTANT ; EXPRESSION ; MOUSE
Subjects:
Departments: Faculty of Health and Medicine > Biomedical & Life Sciences
ID Code: 66861
Deposited By: ep_importer_pure
Deposited On: 01 Oct 2013 00:07
Refereed?: Yes
Published?: Published
Last Modified: 21 Sep 2017 05:49
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/66861

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