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The role of TGF-βs in mammalian development and neoplasia

Akhurst, Rosemary J. and Fitzpatrick, David R. and Fowlis, Deborah J. and Gatherer, Derek and Millan, Fergus A. and Slager, Hans (1992) The role of TGF-βs in mammalian development and neoplasia. Molecular Reproduction and Development, 32 (2). pp. 127-135. ISSN 1040-452X

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Abstract

To date, three mammalian TGF-beta isoforms have been identified, each encoded by different genetic loci. Through each is very similar in primary amino acid structure, there are clear differences both in the mature bioactive peptide region and in the latency-associated peptide, which could potentially confer differential biological specificity. As one route to investigate differential biological function in vivo we have used gene specific probes for in situ hybridization studies to examine the distribution of RNA transcripts during mammalian embryogenesis. Mouse embryos from 6 to 14.5 gestational age and human embryos from 32 to 57 days post-fertilization have been probed. A general conclusion from these studies is that each TGF-beta gene has a distinct, through overlapping, pattern of transcript distribution and that this pattern, in most cases, is conserved between mouse and man. We have focused on the biological function the TGF-betas play in certain epithelia and in cardiogenesis, which will be discussed in this presentation.

Item Type: Article
Journal or Publication Title: Molecular Reproduction and Development
Uncontrolled Keywords: CARDIOGENESIS ; EPITHELIA ; MOUSE DEVELOPMENT ; TGF-BETA ; TRANSFORMING GROWTH-FACTOR ; MOUSE EPIDERMIS ; EXPRESSION ; EMBRYO ; CELLS ; HEART ; RNA ; DIFFERENTIATION ; PROLIFERATION ; EMBRYOGENESIS
Subjects:
Departments: Faculty of Health and Medicine > Biomedical & Life Sciences
ID Code: 66840
Deposited By: ep_importer_pure
Deposited On: 27 Sep 2013 09:14
Refereed?: Yes
Published?: Published
Last Modified: 20 Sep 2017 01:39
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/66840

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