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Adaptation of standard spreadsheet software for the analysis of DNA sequences

McEwan, Neil R. and Gatherer, Derek (1998) Adaptation of standard spreadsheet software for the analysis of DNA sequences. Biotechniques, 24 (1). 131-136, 138. ISSN 0736-6205

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This paper presents use of spreadsheet software to derive various statistics on nucleotide and codon distribution and frequency from gene sequence data, including chi 2 test and their derivatives, and proportion of nucleotides in the third position. The basic principles can be easily extended to other more complex functions. In addition, it can be used to translate a nucleic acid sequence into a protein sequence or to produce a codon usage table. This adaptation permits sequence analysis without expensive dedicated software and easy modification of the analysis according to the user's requirements. It is also ideal for introducing biological science students to the programming potential of spreadsheets.

Item Type: Journal Article
Journal or Publication Title: Biotechniques
Uncontrolled Keywords: Base Sequence ; Codon ; Molecular Sequence Data ; Sequence Analysis, DNA ; Software
Departments: Faculty of Health and Medicine > Biomedical & Life Sciences
ID Code: 66835
Deposited By: ep_importer_pure
Deposited On: 26 Sep 2013 16:39
Refereed?: Yes
Published?: Published
Last Modified: 15 Oct 2018 15:29
Identification Number:

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