Lineage structures in the genome sequences of three Epstein-Barr virus strains

McGeoch, Duncan J. and Gatherer, Derek (2007) Lineage structures in the genome sequences of three Epstein-Barr virus strains. Virology, 359 (1). pp. 1-5. ISSN 0042-6822

Full text not available from this repository.

Official URL: https://doi.org/10.1016/j.virol.2006.10.009

Abstract

Whole genome sequences for three Epstein-Barr virus strains (B95-8, GD1 and AG876) were aligned and compared. In addition to known variable loci (including type-specific alleles for the EBNA2, EBNA3A, EBNA3B and EBNA3C genes, plus the EBNA1 and LMP1 genes), seven large-scale regions of lower-level diversity were identified with strains at each in two major groupings. All three possible patterns of strain associations were represented across the seven loci. Tree-building studies supported the existence of two distinct lineages in each case, and occurrence of recombination between lineages therefore has to be invoked to account for the observed genotypes of virus strains.

Item Type:

Journal Article

Journal or Publication Title:

Virology

Uncontrolled Keywords:

/dk/atira/pure/subjectarea/asjc/2400/2406

Subjects:

?? BASE SEQUENCEDNA, VIRALEVOLUTION, MOLECULARGENETIC VARIATIONGENOME, VIRALGENOTYPEHERPESVIRUS 4, HUMANRECOMBINATION, GENETICSEQUENCE ALIGNMENTSEQUENCE HOMOLOGY, NUCLEIC ACIDVIROLOGY ??

Departments:

Faculty of Health and Medicine > Biomedical & Life Sciences

ID Code:

66833

Deposited By:

ep_importer_pure

Deposited On:

26 Sep 2013 15:36

Refereed?:

Yes

Published?:

Published

Last Modified:

19 Sep 2023 01:09

URI:

https://eprints.lancs.ac.uk/id/eprint/66833