Urbaniak, Michael D. and Frost, Lisa M. and Bingham, John P. and Kelland, Lloyd R. and Hartley, John A. and Woolfson, Derek N. and Caddick, Stephen (2003) Chemical synthesis and cytotoxicity of dihydroxylated cyclopentenone analogues of neocarzinostatin chromophore. Bioorganic and Medicinal Chemistry Letters, 13 (12). pp. 2025-2027. ISSN 0960-894X
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Abstract
Compounds containing the naphthoate moiety of Neocarzinostatin chromophore or 2-hydroxynaphthoate have been synthesized and evaluated for cytotoxic activity against a leukemia cell line and a small panel of human-tumor cell lines. Those compounds containing a cyclopentenone moiety were active, with the carbonyl group being essential for biological activity.