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Vesicles from peptidic side-chain polymers synthesized by atom transfer radical polymerization

Adams, Dave J. and Atkins, Derek and Cooper, Andrew I. and Furzeland, Steve and Trewin, Abbie and Young, Iain (2008) Vesicles from peptidic side-chain polymers synthesized by atom transfer radical polymerization. Biomacromolecules, 9 (11). pp. 2997-3003. ISSN 1525-7797

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Abstract

Block copolymers can adopt a wide range of morphologies in dilute aqueous solution. There is a significant amount of interest in the use of block copolymer vesicles for a number of applications. We show that a series of oligo(valine) and oligo(phenylalanine) peptides coupled to a methacrylic group can be prepared by conventional peptide coupling techniques. These can be successfully polymerized by atom transfer radical polymerization (ATPP) in hexafluoroisopropanol (HFIP) giving access to poly(ethylene oxide)-b-poly(side-chain peptides). Many of these polymers self-assemble to form vesicles using an organic to aqueous solvent exchange. One example with a divaline hydrophobic block gives a mixture of toroids and vesicles. Circular dichroism demonstrates that secondary structuring is observed in the hydrophobic region of the vesicle walls for the valine side-chain containing polymers.

Item Type: Article
Journal or Publication Title: Biomacromolecules
Uncontrolled Keywords: BLOCK-COPOLYMER VESICLES ; TRANSMISSION ELECTRON-MICROSCOPY ; STIMULI-RESPONSIVE VESICLES ; DIBLOCK COPOLYMERS ; BETA-SHEET ; BIODEGRADABLE POLYMERSOMES ; DEFINED POLYPEPTIDES ; TRIBLOCK COPOLYMERS ; LENGTH DISTRIBUTION ; DILUTE-SOLUTION
Subjects:
Departments:
ID Code: 65949
Deposited By: ep_importer_pure
Deposited On: 12 Aug 2013 11:56
Refereed?: Yes
Published?: Published
Last Modified: 21 Sep 2017 05:45
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/65949

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