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The genetics of the repair of 5-azacytidine-mediated DNA damage in the fission yeast Schizosaccharomyces pombe.

Hegde, V. and McFarlane, R.J. and Taylor, Elaine M. and Price, Clive (1996) The genetics of the repair of 5-azacytidine-mediated DNA damage in the fission yeast Schizosaccharomyces pombe. Molecular and General Genetics, 251 (4). pp. 483-492.

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Abstract

We have recently demonstrated thatSchizosaccharomyces pombe cells treated with the nucleoside analogue 5-azacytidine (5-azaC) require previously characterised G2 checkpoint mechanisms for survival. Here we present a survey of known DNA repair mutations which defines those genes required for survival in the presence of 5-azaC. Using a combination of single-mutant and epistasis analyses we find that the excision, mismatch and recombinational repair pathways are all required in some degree for the repair of 5-azaC-mediated DNA damage. There are distinct differences in the epistatic interactions of several of the repair mutations with respect to 5-azaC-mediated DNA damage relative to UV-mediated DNA damage.

Item Type: Article
Journal or Publication Title: Molecular and General Genetics
Uncontrolled Keywords: 5-Azacytidine ; Fission yeast ; DNA repair
Subjects:
Departments: Faculty of Health and Medicine > Medicine
Faculty of Health and Medicine > Biomedical & Life Sciences
ID Code: 60126
Deposited By: ep_importer_pure
Deposited On: 26 Nov 2012 14:10
Refereed?: Yes
Published?: Published
Last Modified: 26 Nov 2012 14:10
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/60126

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