Hegde, V. and McFarlane, R.J. and Taylor, Elaine M. and Price, Clive (1996) The genetics of the repair of 5-azacytidine-mediated DNA damage in the fission yeast Schizosaccharomyces pombe. Molecular and General Genetics, 251 (4). pp. 483-492. ISSN 1432-1874Full text not available from this repository.
We have recently demonstrated thatSchizosaccharomyces pombe cells treated with the nucleoside analogue 5-azacytidine (5-azaC) require previously characterised G2 checkpoint mechanisms for survival. Here we present a survey of known DNA repair mutations which defines those genes required for survival in the presence of 5-azaC. Using a combination of single-mutant and epistasis analyses we find that the excision, mismatch and recombinational repair pathways are all required in some degree for the repair of 5-azaC-mediated DNA damage. There are distinct differences in the epistatic interactions of several of the repair mutations with respect to 5-azaC-mediated DNA damage relative to UV-mediated DNA damage.
|Journal or Publication Title:||Molecular and General Genetics|
|Uncontrolled Keywords:||5-Azacytidine ; Fission yeast ; DNA repair|
|Departments:||Faculty of Health and Medicine > Medicine|
Faculty of Health and Medicine > Biomedical & Life Sciences
|Deposited On:||26 Nov 2012 14:10|
|Last Modified:||03 Nov 2015 16:46|
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