Hegde, V. and McFarlane, R.J. and Taylor, Elaine M. and Price, Clive (1996) The genetics of the repair of 5-azacytidine-mediated DNA damage in the fission yeast Schizosaccharomyces pombe. Molecular and General Genetics, 251 (4). pp. 483-492.
Full text not available from this repository.Abstract
We have recently demonstrated thatSchizosaccharomyces pombe cells treated with the nucleoside analogue 5-azacytidine (5-azaC) require previously characterised G2 checkpoint mechanisms for survival. Here we present a survey of known DNA repair mutations which defines those genes required for survival in the presence of 5-azaC. Using a combination of single-mutant and epistasis analyses we find that the excision, mismatch and recombinational repair pathways are all required in some degree for the repair of 5-azaC-mediated DNA damage. There are distinct differences in the epistatic interactions of several of the repair mutations with respect to 5-azaC-mediated DNA damage relative to UV-mediated DNA damage.
| Item Type: | Article |
|---|---|
| Journal or Publication Title: | Molecular and General Genetics |
| Uncontrolled Keywords: | 5-Azacytidine ; Fission yeast ; DNA repair |
| Subjects: | UNSPECIFIED |
| Departments: | Faculty of Health and Medicine > Medicine Faculty of Health and Medicine > Biomedical & Life Sciences |
| ID Code: | 60126 |
| Deposited By: | ep_importer_pure |
| Deposited On: | 26 Nov 2012 14:10 |
| Refereed?: | Yes |
| Published?: | Published |
| Last Modified: | 26 Nov 2012 14:10 |
| Identification Number: | |
| URI: | http://eprints.lancs.ac.uk/id/eprint/60126 |
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